Fig. 1

Cell-type transcriptional signature masks the sex effect. a Overview of the datasets used in this study. All four datasets include samples from male and female mice, from some or all of ImmGen 11 cell set, whose cell types are shown in the tree on the top. On the bottom, details of the four datasets used. PC peritoneal cavity, Sp spleen, CNS central nervous system, ATAC-seq Assay for Transposase-accessible Chromatin, GN granulocytes, DC dendritic cells, MF macrophages, T4 CD4⁺ T cells, T8 CD8⁺ T cells, Treg regulatory T cells, NK natural killer cells, NKT natural killer T cells, Tgd gamma delta T cells. b Pearson correlation matrix of the samples comprising datasets A and B (including the entire 11 cell set) for the 2904 genes that are expressed in both datasets, sorted by cell type and sex. Black rectangles mark samples of the same cell type. Source data for b are provided as a Source Data file