Fig. 6

Unilateral blockade of NMDARs in NAc core did not abolish learning in most subjects. a Microinjection schedule. VEH: vehicle. b Cumulative performance index records on S+ (left) and S− (right) trials in 11 animals that, despite receiving unilateral intra-accumbens AP5 injections during training, were able to acquire cued approach behavior. Each subject’s behavior is represented by a black line. Letters identify different subjects. c Left: Mean ± SEM entry probability during the S+ (light blue), S− (dark blue), or pre-cue 10 s ITI window (gray) with respect to the trial in which the change point occurred. Before change point, the overall rate of receptacle entry shows a steady increase until, at the change point, the rate of cued entry continues to increase while the rate of uncued entry stabilizes. Right: same as left panel but for latency and ITI pseudolatency. d In subjects that received unilateral AP5 injections prior to each training session, S+ performance index and S+ entry probability increased after change point (***p < 0.001; t test). S+ latency declined (***p < 0.001; t test), while the ITI pseudolatency did not change after change point (p = 0.241; t test); n.s. not significant