Fig. 3

The forward-oriented vector achieves long-term marking levels in long-term hematopoietic repopulating cells in rhesus macaques similar to a standard gene marking vector. a–c We compared the forward-oriented vector with a standard gene marking vector including a GFP or YFP gene in the rhesus competitive repopulation assay. In two animals (ZG26 and ZH05), GFP and YFP gene-marking levels with the forward-oriented vector were evaluated by GFP- or YFP-positive percentages (a) and VCNs (b, c) for 5 years, as compared with a standard GFP or YFP-marking vector