Fig. 3
From: A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
The Yoda1-insensitive A2094W mutant is mechanosensitive. a Example of pressure-elicited ionic current traces for mPZ1 WT and the A2094W mutant obtained in transfected ΔPZ1 cells clamped at −80 mV. For clarity, only few traces are shown. b Mean I/Imax values plotted for WT (n = 8) and the A2094W mutant (n = 6) for comparison. Data are collected from n cells. Lines correspond to curve fitting using a Boltzmann equation. Source data are provided as a Source Data file. Error bars = standard errors of mean values
