Fig. 2 | Nature Communications

Fig. 2

From: Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Fig. 2The alternative text for this image may have been generated using AI.

Genomic features at four EGPA-associated loci. Genomic positions from the hg19 genome build, representative RefSeq genes, long-range DNA interactions, genetic variant associations with EGPA, causal variant mapping (expressed as posterior probabilities, PP) and H3K4 mono-methylation data are shown for (a) the BCL2L11 region, (b) the LPP region, (c) the C5orf56-IRF1-IL5 region and (d) the 10p14 intergenic region. Arrows indicate direction of transcription. P-values for genetic association are from a linear mixed model (BOLT-LMM). For further details regarding the promoter enhancer interaction mapping, including cell types analysed at each locus, see the ‘Methods’ section and Supplementary Fig. 7

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