Fig. 8
From: Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
IL-22 induces downregulation of pancreatic enzymes related genes in acinar cell cultures in vitro. Acinar cells from WT (IL-10R2+/+) and IL-10R2−/− mice were cultured in the presence of IL-22 recombinant protein. Sixty hours after culture, cells were analyzed for the expression of pancreas transcription factor 1a (Ptf1a), syncollin (Sycn), amylase 2a (Amy2a), and serine protease 2 (Prss2) by qPCR. Note the downmodulation of several pancreatic related genes by WT acinar cells cultured with IL-22. IL-22 did not reduce the expression of pancreatic related genes in IL-10R2 -deficient cells. Data are shown as mean ± SEM, statistical analysis by one-way ANOVA. *p < 0.05, **p < 0.01, and ***p < 0.001. Source data are provided as a Source Data file
