Table 2 Comparison of heritability between European (EUA) and African ancestry (AFA) studies

From: International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Sample

N

N

10% prev

30% prev

50% prev

Cases

Controls

h 2 SNP

95% CI

h 2 SNP

95% CI

h 2 SNP

95% CI

p-value

All

 EUA

9354

25,175

0.04

0.02–0.06

0.05

0.02–0.08

0.05

0.02–0.08

1.3 × 10−4

 AFA

3163

9459

0.02

−0.04 to 0.09

0.03

−0.06 to 0.12

0.04

−0.06 to 0.13

0.22744

Men

 EUA

4412

17,380

0.02

−0.02 to 0.05

0.02

−0.02 to 0.07

0.03

−0.03 to 0.08

0.15951

 AFA

1195

4361

0.02

−0.14 to 0.18

0.03

−0.2 to 0.25

0.03

−0.21 to 0.27

0.41127

Women

 EUA

4689

5874

0.08

0.03–0.13

0.12

0.05–0.19

0.13

0.05–0.20

4.0 × 10−4

 AFA

1761

4435

0.12

−0.01 to 0.25

0.17

−0.01 to 0.35

0.18

−0.01 to 0.38

0.028

  1. Analyses are performed using GCTA in both sexes and for men and women separately and include all subjects used in the EUA and AFA GWAS with access to individual-level genotype data. Number of SNPs ranges from 4,071,335 to 4,863,146.
  2. P-value is testing if h2SNP is different from zero and applies to all prevalences
  3. h2SNP mean SNP-based heritability, 95% CI 95% confidence interval, prev prevalence
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