Fig. 1 | Nature Communications

Fig. 1

From: N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Fig. 1The alternative text for this image may have been generated using AI.

CircNSUN2 was upregulated in CRCs with liver metastasis (LM). a Top, flowchart illustrating the screening criteria of potential regulatory circRNAs enriched in CRCs. Bottom, clustered heatmap showing the dysregulated expression of circRNAs occurrent in both two CRC samples (the |average normalized fold change| ≥ 1.3) within susceptibility loci of CRC analyzed by CircRNAs Microarray. b qRT-PCR analysis of circNSUN2 expression in 97 CRC tissues and matched adjacent normal tissue. Data represent mean ± S.D., the P value was determined by a two-tailed paired Student’s t test. c Kaplan−Meier analysis of OS in CRC patients with low versus high expression the circNSUN2 from SYSUCC cohorts. The P value was determined by a Log-rank test. d qRT-PCR analysis of circNSUN2 expression from 18 normal colorectal tissues, 22 colorectal adenomas, 97 CRC patients without liver metastasis and 25 CRC patients with liver metastasis. Data represent mean ± S.D., the P values were determined by an unpaired Student’s t test. e qRT-PCR analysis of circNSUN2 expression in 20 pairs of primary colorectal cancer tissues (PC) and matched liver metastasis tissues (LM) surgically obtained from the same patients. Data represent mean ± S.D., the P value was determined by a two-tailed paired Student’s t test. f qRT-PCR analysis of circNSUN2 expression in serum from 18 normal control, 20 CRC patients without LM and 20 CRC patients with LM from the SYSUCC. Data represent mean ± S.D., the P values were determined by an unpaired Student’s t test

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