Fig. 3 | Nature Communications

Fig. 3

From: N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Fig. 3The alternative text for this image may have been generated using AI.

CircNSUN2 promotes metastasis of CRC. a, b Decreased (a) or increased (b) tumor metastasis formed in the livers of mice through the inferior hemispleen implantation of circNSUN2-konckdown (a) or circNSUN2-overexpression (b) TC71 PDX cells. Top, left, representative bioluminescent images of livers for each experimental group at 8 weeks. Top, right, statistical analysis of bioluminescent tracking plots. Bottom, left, representative liver. Bottom, right, the number of metastatic nodules formed in the lungs of mice for each group (n = 6 mice / group). Data represent mean ± S.D.; dot plot reflects data points from independent experiment. The P values were determined by a two-tailed unpaired Student’s t test. c, d Decreased (c) or increased (d) tumor metastasis formed in the lungs of mice through vein tail injection of circNSUN2-konckdown (c) or circNSUN2-overexpression (d) PDX cells. Top, left, representative bioluminescent images of lungs for each experimental group during 6 weeks. Top, right, statistical analysis of bioluminescent tracking plots. Bottom, left, representative lung and representative HE staining of lung metastatic lesions, Original magnification, ×4, scale bar, 100 µm. Bottom, right, the number of metastatic nodules formed in the lungs of mice for each group (n = 6 mice/group). Data represent mean ± S.D.; dot plot reflects data points from independent experiment. The P values were determined by a two-tailed unpaired Student’s t test. Source data are provided as a Source Data file

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