Fig. 1 | Nature Communications

Fig. 1

From: Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Fig. 1

Functionally distinct subpopulations of qHSCs derive from alternative embryological origins. a Lineage labelling of hepatic mesothelial cells and their progeny was induced at E10.5 in WT1CreERT2/+;Ai14 animals, and qHSCs isolated or livers examined in adulthood. b Adult WT1CreERT2/+;Ai14 livers, labelled at E10.5, were stained for lineage label (RFP) and qHSC markers (desmin and PDGFRβ); 68.4 ± 3.46% qHSCs were lineage label positive (mean ± s.e.m., n = 3, scale bars 100 μm). c The presence of the lineage label was the major component describing variation in differentially expressed genes between lineage-labelled and unlabelled populations of qHSCs isolated from adult WT1CreERT2/+;Ai14 livers (n = 3), labelled at E10.5. d GO term analysis of differentially expressed genes between lineage-labelled and unlabelled qHSCs showed distinct functional profiles depending on origin

Back to article page