Fig. 10 | Nature Communications

Fig. 10

From: Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Fig. 10

WT1 is a paradoxical negative regulator of fibrogenesis in distinct subpopulations of aHSCs defined by WT1 expression. WT1-positive subpopulations in liver injury are generated by activation of specific progenitors that derive from the embryonic hepatic mesothelium in early development. Developmental origin determines the functional categorisation of qHSCs; those derived from the mesothelium demonstrate engagement of vascular regulatory pathways, whilst those from non-mesothelial sources have immunomodulatory transcriptional profiles

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