Fig. 6 | Nature Communications

Fig. 6

From: Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Fig. 6

The transcriptional profiles of aHSC populations defined by WT1 expression are classically activated but distinct, with enhanced scar-related processes in WT1-intermediate cells. a GO term analysis of differentially expressed genes between subpopulations of aHSCs defined by WT1 expression demonstrate significant differences in profiles between all subpopulations, with WT1-high and WT1-intermediate populations showing fewer differences. b Specific mapping of differentially expressed genes to GO terms for indicative scarring responses demonstrate the enhancement in WT1-intermediate aHSCs compared with WT1-high aHSCs. c The transcriptome, determined by RNAseq, of aHSCs isolated from PDGFRβCre;WT1GFP/+ animals (n = 6) with liver fibrosis induced by iterative injury with CCl4 was compared with that of quiescent lineage-label positive HSCs from WT1CreERT2/+;Ai14 animals (n = 3) induced at E10.5. Gene ontology terms mapped to differentially expressed genes for WT1-high cells demonstrate engagement of cellular processes associated with the HSC activation paradigm

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