Table 1 A total of 31 previously unreported significant loci in mLOY
From: GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
SNP | Chr | BP | Gene | A0 | A1 | A1frq | Beta | P |
|---|---|---|---|---|---|---|---|---|
rs34468831 | 1 | 3097312 | PRDM16 | GA | G | 0.37 | −0.032 | 3 × 10−12 |
rs527504 | 1 | 33392427 | TMEM54;RNF19B | G | A | 0.19 | −0.032 | 4.1 × 10−9 |
rs17049722 | 2 | 58976863 | LINC01122 | C | T | 0.17 | 0.038 | 4.4 × 10−12 |
2: 136879065 | 2 | 136879065 | CXCR4 | G | ALU | 0.32 | −0.035 | 9.3 × 10−13 |
rs34778241 | 3 | 71771215 | EIF4E3 | T | TG | 0.71 | −0.030 | 2.1 × 10−9 |
rs2811487 | 3 | 128331879 | LINC01565;RPN1 | G | A | 0.36 | 0.027 | 6.8 × 10−10 |
rs871134 | 4 | 7044380 | CCDC96 | C | T | 0.49 | −0.032 | 1.4 × 10−14 |
rs2853677 | 5 | 1287194 | TERT | G | A | 0.70 | 0.027 | 2.1 × 10−9 |
rs10948011 | 6 | 42024285 | TAF8 | G | A | 0.23 | 0.035 | 4 × 10−12 |
rs35355140 | 7 | 27204732 | HOXA9 | C | A | 0.14 | 0.045 | 2.3 × 10−13 |
rs11769630 | 7 | 50257703 | C7orf72;IKZF1 | T | A | 0.13 | −0.057 | 3.7 × 10−19 |
rs59543286 | 7 | 135351310 | C7orf73 | A | C | 0.23 | 0.059 | 8 × 10−32 |
rs55727837 | 7 | 149428602 | KRBA1 | G | T | 0.11 | 0.061 | 9.7 × 10−20 |
rs12668837 | 7 | 158500805 | NCAPG2;ESYT2 | C | T | 0.46 | −0.026 | 1.8 × 10−9 |
rs189309686 | 8 | 59509355 | NSMAF | C | T | 0.25 | 0.027 | 4.4 × 10−8 |
rs10692222 | 8 | 130597362 | CCDC26 | C | CATT | 0.43 | 0.025 | 6 × 10−9 |
rs2804301 | 9 | 603916 | KANK1 | G | A | 0.24 | −0.027 | 4.4 × 10−8 |
rs9299129 | 9 | 109638167 | ZNF462 | A | G | 0.23 | 0.030 | 2.2 × 10−9 |
rs138423884 | 9 | 129855937 | ANGPTL2;RALGPS1 | A | G | 0.038 | 0.079 | 1.3 × 10−12 |
rs2646425 | 10 | 8470387 | LINC00708;LOC105376398 | C | T | 0.31 | 0.028 | 4.3 × 10−10 |
rs12225799 | 11 | 241124 | PSMD13 | C | G | 0.13 | −0.036 | 1.1 × 10−8 |
rs2237896 | 11 | 2858440 | KCNQ1 | G | A | 0.40 | 0.043 | 1.7 × 10−22 |
rs74843651 | 11 | 14292987 | SPON1;RRAS2 | G | T | 0.052 | 0.055 | 2.2 × 10−8 |
rs10849448 | 12 | 6493351 | LTBR | A | G | 0.81 | −0.050 | 1.5 × 10−18 |
rs34324 | 12 | 12877926 | APOLD1 | C | A | 0.43 | −0.039 | 3.1 × 10−19 |
rs548509555 | 13 | 57601900 | MIR5007;PRR20B | T | TA | 0.20 | 0.032 | 8.1 × 10−9 |
rs9921295 | 16 | 50027130 | ZNF423;CNEP1R1 | T | G | 0.33 | 0.031 | 4 × 10−12 |
rs1859259 | 16 | 57596552 | GPR114 | C | T | 0.58 | −0.025 | 1.1 × 10−9 |
rs77406149 | 17 | 53076247 | STXBP4 | A | G | 0.20 | 0.035 | 2.5 × 10−10 |
rs79058858 | 19 | 49979789 | FLT3LG | C | T | 0.0052 | 0.16 | 1.4 × 10−8 |
rs117587217 | 21 | 16631171 | NRIP1;USP25 | T | C | 0.016 | −0.10 | 9.7 × 10−9 |
