Fig. 2 | Nature Communications

Fig. 2

From: Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

Fig. 2

Identification of TFs with altered accessibility in plasma samples from patients with cancer. a TFBS analysis of a plasma sample from a healthy donor (NPH001). Each point represents a TF, the y-axis displays the accessibility values, and the x-axis illustrates the overall z-score, as a measure of deviation in accessibility from normal control samples. In the samples from healthy donors (compared with every remaining healthy donor), only a few TFs exceeded a z-score of ±3 (dotted gray lines) and none the ±5 z-score (red lines) threshold. b An overall z-score plot as in (a), but with a plasma sample derived from a patient with prostate cancer (P40). c Overall z-score plot as in (a) for plasma sample C2_6. d Nucleosome position profiles from plasma DNA of healthy controls (gray profiles) and two plasma samples derived from a patient C2 with colon cancer (blue and red) for TF EVX2. e Bar charts of overall z-score plots for merged breast, prostate, and colon pools. The left panel displays TFs with increased accessibility in at least one tumor entity; the right panel summarizes the accessibilities of hematopoietic-related TFs. Bars represent single data points

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