Fig. 2 | Nature Communications

Fig. 2

From: Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

Fig. 2

Function characterization of the LG depot. a Photographs of the sol-to-gel transition upon adding water and changing the temperature. b Temperature-responsive storage (G′) and loss (G″) modulus changes of the LG with an SPC/GDO mass ratio of 35/65. The phase transition temperature of the LG is 39.5 °C. c Modulus changes of the LG with an SPC/GDO mass ratio of 35/65 with three thermal cycles of heating (43 °C) and cooling (37 °C). d Morphology changes of the gel in 1 × PBS with 2% lipase over 14 d. e In vivo degradation behavior and tissue biocompatibility of the in situ-formed LG with H&E staining of the surrounding skin at different testing times (scale bar: 200 μm). f Fluorescence IVIS images depicting the in vivo retention of IR820 solution, IR820@LG with or without the NIR laser (808 nm). g Mean fluorescence intensity (MFI) of IR820 solution, IR820@LG with or without the NIR laser (808 nm) in non-tumor-bearing mice. Data are mean ± SEM (n = 3 biologically independent samples)

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