Table 3 Results of antimicrobial susceptibility and mutation analysis of experimental evolution in Shigella sonnei
From: Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei
Conditiona | MIC-CIP (μg/mL) | MIC-NAL (μg/mL) | Resistance mutations | Other mutationsd | Genomic deletion |
|---|---|---|---|---|---|
cipS-VN: D0b | 0.25 | 64 (sat) | |||
cipS-VN: M9-A | 0.19 | 64 (sat) | cysE (P252S) | ||
cipS-VN: M9-B | 0.25 | 64 (sat) | cysE (P252T); clpA (T374I); metJ (D76N, A61E); rpoS (Q161P) | ||
cipS-VN: NAL-A | 0.5 | >256 | emrRc (fs); parE (P571S) | cysE (A33E); cysE (S249R); cysB (P145L) | |
cipS-VN: NAL-B | 0.38 | >256 | acrR (fs); emrR (fs) | cysE (Q228K); dinG (fs, 2 a.a deletion); metJ (R78P, A13T) | |
cipS-VN: CIP-A | 0.38 | >256 | parE (S458L) | cysE (fs); cysE (P252T) | treF-yhjA-yhi-hde-slp-iucABCD-iutA |
cipS-VN: CIP-B | 0.75 | >256 | parE (2 a.a insertion) | cysE (M256I) | treF-yhjA-yhi-hde-slp-iucABCD-iutA |
cipR-VN: D0 | 8 | >256 | |||
cipR-VN: M9-A | 8 | NA | rpoS (R277L); iucA (stop codon) | ||
cipR-VN: M9-B | 6 | NA | rpoS (R301H); iucD (L113P); ycjC (P47S); SSON_2732 (2 a.a insertion) | ||
cipR-VN: NAL-A | 12 | NA | emrR (fs) | SSON_1790 (stop codon); hemX (fs) | |
cipR-VN: NAL-B | 8 | NA | emrR (I27 deletion) | SSON_2588 (A93T) | |
cipR-VN: CIP-A | 16 (sat) | NA | rob (G245R) | eutQ (fs) | |
cipR-VN: CIP-B | 16 (sat) | NA | rob (Q194K) emrR (fs) | SSON_1804 (N200K) |
