Fig. 1

Top recurrent genes harbored somatic variants and somatic CNVs. a Left panel, bar plot shows the proportion of 161 ESCC samples with somatic mutations in the specific genes. Right panel, occurrence of the top 23 ranked somatically mutated genes identified by the cancer panel. Mutation subtypes (Missense, Stopgain, Stoploss, Splice, Frameshift, and Non-frameshift) are denoted by color. b Heatmap of the top recurrent genes associated with the top recurrent somatic CNVs in the 161 ESCC samples. The genes with recurrence of more than 10% are shown here. Mutation subtypes (Gain and Loss) are denoted by color