Fig. 4
From: An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
Transcriptome analysis of heterozygous RE6-9+/− mice. a, b Absolute expression (a) and fold change expression (b) levels of Scn5a, Scn10a and genes within and outside Scn5a TAD from ventricles (left) and brain (right) from 2-week old RE6-9+/− mice compared to wiltype (WT). Bars represent mean ± SEM and P values were calculated using unpaired Student’s t test. WT n = 4; RE6-9+/− n = 7. ***P < 0.001. c UCSC browser view of the Scn5a-Scn10a locus showing RNA-seq profile of WT and RE6-9+/− mice. d–f Vulcano plot (d), MA plot (e) and scatter plot (f) of approximately 15.000 transcripts showing only Scn5a is highly significantly (P = 3.75e-27) downregulated in RE6-9+/− mice compared to WT. P values were corrected for multiple testing using the false discovery rate (FDR) method of Benjamini-Hochberg (P < 0.05). Source data are provided as a Source Data file
