Fig. 1 | Nature Communications

Fig. 1

From: An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Fig. 1The alternative text for this image may have been generated using AI.

Sequential delivery is effective across all CPP types. Polymer dose-dependent uptake of the MK2i peptide (co-delivery of pre-complexed polymer/peptide) fused to a three separate cationic, non-amphipathic CPPs and b two different amphipathic CPPs. Sequential polymer then peptide delivery polymer dose-dependent uptake of the MK2i peptide fused to c three separate cationic, non-amphipathic CPPs and d two different amphipathic CPPs. e Polymer dose-dependent uptake of the YARA CPP fused to two separate therapeutic peptide sequences (MK2i and VASP) when co-delivered. f Polymer dose-dependent uptake of the VASP peptide without a CPP. The mass ratios used for all data shown are 3:1, 1:1, 1:3, 1:5, 1:10, and 1:20 peptide:polymer. Error bars represent SEM. Non-normalized uptake for all data presented in this figure is shown in Supplementary Fig. 4

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