Fig. 5 | Nature Communications

Fig. 5

From: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Fig. 5The alternative text for this image may have been generated using AI.

A model for two independent translational repression programs in Plasmodium sporozoites. One regulatory program acts upon mRNAs that are highly abundant in oocyst sporozoites to impose translational repression, which is relieved in salivary gland sporozoites and enables protein translation to occur. Transcripts encoding for proteins important to host cell traversal and initial infection are regulated in this manner. A second regulatory program translationally represses mRNAs throughout sporozoite maturation, which is hypothesized to be relieved following transmission and infection of a hepatocyte to promote liver stage development

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