Fig. 1: Characterization of βICKO mice phenotype.
From: Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
a Intraperitoneal glucose tolerance test at 12 week post induction (n = 6, p < 0.0001 (GTT, repeated measures one-way ANOVA); p = 0.002 (AUC, one-way ANOVA, Holm-Sidak multiple comparison) mean ± s.e.m.). b Insulin-secretion test. (n = 3, p < 0.0001 (GTT, repeated measures one-way ANOVA), mean ± s.e.m.) 12 weeks post induction. c β-cell mass 6 weeks post induction (n = 3, mean ± s.d.). d β-cell mass 20 weeks post induction (n = 3, p = 0.0006 (t test), mean ± s.d.). e Percentage of apoptotic beta cells over total of beta cells. Representative images of control and treated animal islets. Nkx6.1 shown in red, and caspase-3 in green (n = 3 animals, n = 10 islet per animal, 20 weeks post induction, scale bar 50 µm, p = 0.0216, mean ± s.d.). f Dynamic insulin secretion of isolated βICKO islets (Tx-treated shown in gray, veh shown in black). AUC quantification of first phase (time 18:00 to 30:00 min) and total secretion (from 18:00 to 48:00 min) (First phase p = 0.0058; total secretion p = 0.0005 (t test), islets pooled from n = 10 animals, experiment repeated n = 4, and insulin measured n = 2 per experiment, mean ± s.d.
