Fig. 1

Genomic aberration profiling identified four molecular subtypes that correlate with various clinicopathological features. a Patterns of genomic alterations in carcinosarcoma (CS) genomic aberration subtypes (MSI, POLE, CNH, and CNL). Uterine (92) and ovarian (17) samples were sorted according to the number of SNVs within a subtype. Panels from top to bottom: bar plots for number of SNVs (pink) and indels (pale blue); bar plots for number of segments with copy-number aberration (CN gain, red; CN loss, blue); rates in percent of nucleotide substitutions (C > A, indigo; C > G, navy blue; C > T, sky blue; T > A, yellow; T > C, orange; T > G, vermilion); tumor purity; tumor ploidy; histopathological diagnosis of carcinoma components (endometrioid, green; serous, red; clear cell, violet; undifferentiated, pink); and histopathological diagnosis of sarcoma components (ESS, sky blue; RMS, brown; CHS, yellowish brown; others, gray). POLE, POLE-mutated; MSI, microsatellite instability; CNH, copy number high; CNL, copy number low; SNV, single nucleotide variant; CNV, copy number variant; CN, copy number; ESS, endometrial stromal sarcoma; RMS, rhabdomyosarcoma; CHS, chondrosarcoma. b Clinical relevance of CS genomic aberration subtypes. Statistically significant parameters are shown among CS genomic subtypes. Left panel. Relapse-free survival in Kaplan–Meier curve. P-values were computed with log-rank test. Middle panel. Age. P-values were computed with the Mann–Whitney U-test. Right panel. Body mass index (BMI). P-values were computed with the Mann–Whitney U-test. Bars and error bars indicate mean and standard deviation