Fig. 5 | Nature Communications

Fig. 5

From: Clinically relevant molecular subtypes and genomic alteration-independent differentiation in gynecologic carcinosarcoma

Fig. 5

Clonal evolution in the carcinoma and sarcoma elements inferred from SNVs/indels based on the 596-gene panel. Phylogenetic trees are used to represent genetic similarity of the carcinoma and sarcoma components in the primary tumor. A trunk (navy) and a branch (yellow green; carcinoma and cherry color; sarcoma) represent shared and private mutations, respectively. The length of the trunk/branch is proportional to the number of SNVs and indels, and an index beside each tree indicates the number of base pairs. The timing of driver mutation acquisition is shown with an arrow. A case ID is shown on a tree with the color indicating the genomic aberration subtype: blue, POLE; green, MSI; red, CNH; and orange, CNL). Ca, carcinoma; Sa, sarcoma

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