Fig. 7
From: Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
Monocyte profiling from separate set of RMs and AGMs. a PCA analysis of 1000 most variable genes, showing clear separation between AGM (teal) and RM (pink) monocytes, as well as type M1 (dark color) and M2 (light color). Shapes represent time points: circle—baseline, diamond—d7, triangle—d14, square—d28. b Functional enrichment of the AGM and RM monocyte transcriptomic signatures—each consisted of the 300 genes with the strongest positive and negative correlation to the first PC shown in (a). c Number of up- and downregulated genes from AGM and RM rectal mucosa, that overlapped with genes in the AGM or RM monocyte signatures. d Expression levels for predicted upstream regulators of Wound Healing Network genes in the AGM and RM monocytes from peripheral blood. Number indicate the number of regulator target genes in the Wound Healing Network, and p-values pertain to the corresponding enrichment test. Colors and shapes represent species, monocyte subset and time point as in (a). e Heatmap showing expression of Wound Healing Network genes in AGM and RM monocytes, with upregulated genes from axolotl wound healing. Since the most variation was introduced by species and monocyte subset, not time point, we show expression Z-score instead of logFC values. The leftmost column shows what genes are significantly upregulated in axolotl wound healing. Dark blue marks genes upregulated at day 1; light blue marks genes upregulated at day 7
