Fig. 5
From: Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
Ly49-family deletion does not rescue β2M-null NK-cell function. a Flow cytometry analysis of the expression of Ly49-family receptors and NKG2A on splenic CD3−NKp46+ NK cells from WT (red line) and β2m−/− (blue line) mice; Ly49s KO mice (grey filled curve) served as the negative control. b Poly(I:C)-primed splenocytes from the indicated mice were stimulated with tumour target cells. Percentages of IFN-γ+ (left panel) and CD107a+ (right panel) gated CD3−NKp46+ NK cells were analysed. c In vivo rejection of β2M-deficient splenocytes (similar to Fig. 3a). Each symbol represents an individual mouse. Data shown represent two (c) or at least three (b) independent experiments. Mean ± SD is shown. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. Unpaired Student’s t-tests (two-tailed) was used to calculate these values. Source data are provided as a Source Data file
