Table 1 Multivariate Cox-regression analysis of eTIL% score and the clinicopathological factors in whole-slide cohorts #2 and #4 regarding disease-specific overall survival.
From: An open source automated tumor infiltrating lymphocyte algorithm for prognosis in melanoma
Prognostic factor | Cohort #2 (n = 120) | Cohort #4 (n = 76) | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
Age | 0.985 | 0.958–1.013 | 0.289 | 1.014 | 0.979–1.049 | 0.446 |
Sex | 1.601 | 0.876–2.927 | 0.126 | 0.497 | 0.129–1.914 | 0.310 |
Tumor depth | 1.156 | 0.747–1.788 | 0.516 | 1.441 | 0.514–4.043 | 0.488 |
Clarke levels | 1.369 | 0.708–2.645 | 0.350 | NA | NA | NA |
Ulceration | 1.190 | 0.623–2.272 | 0.599 | 1.397 | 0.454–4.293 | 0.560 |
Stage | 1.389 | 0.990–1.948 | 0.057 | 4.463 | 1.365–14.600 | 0.013 |
Location of primary tumor | NA | NA | NA | 0.588 | 0.226–1.529 | 0.276 |
Automated TIL score | 0.143 | 0.063–0.326 | <0.001 | 0.326 | 0.122–0.874 | 0.026 |
