Table 2 Hazard ratio for HIV acquisition by HPV status
From: HPV infection and the genital cytokine milieu in women at high risk of HIV acquisition
HPV Status | Person years (N) | # HIV events | HIV IR/100py (95% CI) | Hazard Ratioa (95% CI) | p-value |
|---|---|---|---|---|---|
Baseline | |||||
Baseline HPV Negative (reference) | 331.4 (204) | 8 | 2.4 (1.0–4.8) | − | − |
Prevalent HPV | 882.1 (575) | 58 | 6.6 (5.0–8.5) | 2.5 (1.2–5.3) | 0.015 |
# prevalent types < 3 | 513.1 (328) | 22 | 4.3 (2.7–6.5) | 1.7 (0.8–3.9) | 0.201 |
# prevalent types ≥ 3 | 369.0 (247) | 36 | 9.8 (6.8–13.5) | 3.8 (1.7–8.2) | <0.001 |
Prevalent Oncogenic types | 625.5 (404) | 46 | 7.4 (5.4–9.8) | 2.8 (1.3–6.0) | 0.008 |
Prevalent Non-oncogenic types | 256.6 (171) | 12 | 4.7 (2.4–8.2) | 1.9 (0.8–4.7) | 0.179 |
Prevalent Cervarix® types | 203.2 (131) | 12 | 5.9 (3.1–10.3) | 2.0 (0.8–5.1) | 0.151 |
Prevalent Gardasil® types | 261.7 (171) | 18 | 6.9 (4.1–10.9) | 2.6 (1.1–6.2) | 0.035 |
Prevalent Gardasil®9 types | 495.9 (322) | 36 | 7.3 (5.1–10.0) | 2.7 (1.2–6.0) | 0.012 |
Non-Gardasil®9 types | 386.2 (253) | 22 | 5.7 (3.6–8.6) | 2.2 (0.9–5.1) | 0.054 |
Longitudinal | |||||
Category 1: Remained HPV negative (reference) | 178.6 (108) | 2 | 1.1 (0.1–4.0) | − | − |
Overlapping HPV Categories | |||||
Acquired any HPV types | 633.1 (405) | 49 | 7.7 (5.7–10.2) | 9.2 (2.1–40.5) | 0.003 |
Cleared any HPV types | 747.3 (477) | 54 | 7.2 (5.4–9.4) | 6.3 (1.5–26.3) | 0.012 |
Persisted any HPV types | 358.7 (236) | 28 | 7.8 (5.2–11.3) | 6.4 (1.5–27.4) | 0.013 |
Mutually Exclusive HPV Categories | |||||
Category 2: Only Cleared | 218.5 (130) | 8 | 3.7 (1.6–7.2) | 2.2 (0.4–11.0) | 0.333 |
Category 3: Only Acquired | 141.6 (85) | 6 | 4.2 (1.6–9.2) | 5.5 (0.9–33.6) | 0.068 |
Category 4: Only Persisted | 52.5 (33) | 1 | 1.9 (0–10.6) | 0.8 (0.0–21.4) | 0.888 |
Category 5: Cleared and Persisted | 90 (61) | 6 | 6.7 (2.4–14.5) | 6.4 (1.3–32.2) | 0.024 |
Category 6: Cleared and Acquired | 275.3 (178) | 22 | 8.0 (5.0–12.1) | 7.8 (1.8–34.3) | 0.006 |
Category 7: Persisted and Acquired | 52.8 (34) | 3 | 5.7 (1.2–16.6) | 5.6 (0.9–34.5) | 0.061 |
Category 8: Cleared, Acquired, and Persisted | 163.4 (108) | 18 | 11 (6.5–17.4) | 10.2 (2.3–45.6) | 0.002 |
