Fig. 8
From: A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation
An EphB/EphrinB code and myosin II contractility control HPD tubulogenesis. a Graphic representation of domain-specific phenotypes observed in ephrinb1, ephrinb2a, ephb3b and ephb4a mutants; y-axis indicates overall severity of phenotypes. b Graphic representation of domain-specific expression of EphrinB1, EphrinB2a, EphB3b and EphB4a in HPD endoderm and surrounding mesoderm at 52 hpf. c Working model of HPD de novo lumen formation focused on the CBD domain. Lumen formation occurs by a multi-step cord hollowing mechanism, which starts with scattered junctional aggregates, transitions through apical/luminal pocket formation and their subsequent coalescence and finally resolves into a single lumen. Apical/luminal pocket coalescence is promoted by ductal EphrinB1/EphrinB2a interaction with mesodermal EphB3b at the tissue interface and actomyosin contractility
