Fig. 3

MGE transplantation increases synaptic inhibition after brain injury. a Representative patch-clamp recordings of IPSCs from granule cells in a control (black), a brain injured mouse injected with media (TBI, gray) or a brain injured mouse implanted with MGE cells (TBI-MGE, blue). Recordings were obtained from slices 45–60 DAT. b Quantification of IPSC frequency. **P = 0.004, control vs TBI; **P = 0.0005, TBI vs TBI-MGE; one-way ANOVA with Bonferroni post hoc test. n = 11 cells from 3 control mice, 12 cells from 3 TBI mice and 13 cells from 3 TBI-MGE mice. c Quantification of IPSC amplitude. d Averaged IPSCs recorded from granule cells in a control mouse (black) and TBI mice receiving media injections (gray) or MGE cells (blue). e Quantification of IPSC 10–90% rise time (RT). **P = 0.003, control vs TBI; **P = 0.0006, TBI vs TBI-MGE; one-way ANOVA with Bonferroni post hoc test. f Quantification of IPSC decay time constant. *P = 0.04, control vs TBI; *P = 0.04, TBI vs TBI-MGE; one-way ANOVA with Bonferroni post hoc test. See Supplementary Table 1 for statistical analyses. Error bars, s.e.m. Source data are provided as a Source Data file