Fig. 2

Reduced adiposity is not due to altered activity, food intake, faecal output or malabsorption. a Daily spontaneous physical activity, (b) food consumption, (c) faecal output and (d, e) energy content of stool in Hdac3^WT and Hdac3^IKO mice. a Spontaneous physical activity was monitored in 4–8-week-old male mice individually housed for 3 days and fed a standard chow diet. b, c Food consumption and faecal output measured in 4–8-week-old individually housed male mice over 5 consecutive days, and fed a standard chow diet. In all cases, values shown are the mean ± SEM of n = 4 (a, b, e) or n=5 (c, d) mice per genotype. *P < 0.05, NS not significant, unpaired t test.