Fig. 1
From: Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
Enantiodivergent Mannich reaction of β,γ-alkynyl-α-imino esters. Reaction conditions for the formation of (S,R)-3: 1 (0.1 mmol), PNBA (0.02 mmol, 20 mol %), Ia/0.5TfOH (0.02 mmol, 20 mol %), 2 (0.3 mmol), MeCN (0.8 mL), −40 °C. Reaction conditions for the formation of (R,S)-3: 1 (0.1 mmol), PNBA (0.02 mmol, 20 mol %), Id/0.5TfOH (0.02 mmol, 20 mol %), 2 (0.3 mmol), DCE (0.8 mL), −40 °C
