Fig. 5
From: Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
Enantiodivergent Mannich reaction of monocyclic ketimines. Reaction conditions for the formation of (S,R)-9: 8 (0.1 mmol), MNBA (0.02 mmol, 20 mol %), Ia/0.5TfOH (20 mol %), 2a (0.3 mmol), MeCN (0.8 mL), −40 °C. Reaction conditions for the formation of (R,S)-9: 8 (0.1 mmol), MNBA (0.02 mmol, 20 mol %), Ie/0.5TfOH (20 mol %), 2a (0.3 mmol), MeCN (0.8 mL), −40 °C
