Fig. 8
From: Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
Enantiodivergent α-amination of aldehydes. Reaction conditions for the formation of (S)-15: 14 (0.1 mmol), MNBA (0.02 mmol, 20 mol %), Ii/0.5TfOH (5 mol %), 2 (0.3 mmol), MeCN (0.8 mL), −20 °C. Reaction conditions for the formation of (R)-15: 14 (0.1 mmol), MNBA (0.02 mmol, 20 mol %), Ie/0.5TfOH (10 mol %), 2 (0.3 mmol), MeCN (0.8 mL), −20 °C. The absolute configuration of 15 was determined by comparison with the reported ref. 69
