Fig. 1: Design of the DNA nanopore.
From: A large size-selective DNA nanopore with sensing applications
a The pseudosymmetric nanopore is based on a hexagonal origami lattice and has a 9-nm inner pore diameter, a 22-nm outer diameter, and a length of 32 nm. b The three flaps are each locked with two dsDNA hybrids that possess an 8-nt toehold for strand displacement opening. c At the top, 27 staple strands are extended with unique 8-nt sequences to allow specific sticky end-mediated dimerization upon mixing A and B nanopores. d Lipidated nucleic acid staples (orange protrusions) are displayed at the surface of the channel and the flaps when opened. e Schematic illustration of the nanopore inserted into a liposome.
