Table 2 Cox-regression analysis of progression-free (a) and disease-specific (b) survival with genomic clustering.

From: Integrated exome and RNA sequencing of dedifferentiated liposarcoma

 

Univariate

Multivariate

 

HR

(95% CI)

P-value

HR

(95% CI)

P-value

(a) Progression-free survival

 Primary tumor site

   Trunk (vs Extremity)a

5.22

(2.08–13.10)

4.29 × 10−4**

4.29

(1.59–11.58)

4.01 × 10−3**

 Surgical margin

   (R2, R1, R0)

2.25

(1.33–3.81)

2.52 × 10−3**

1.62

(0.87–3.01)

0.131

 Genomic cluster

   Cluster 1 (vs 2)

1.82

(1.08–3.04)

0.0234*

2.31

(1.33–4.00)

2.84 × 10−3**

   Cluster 3 (vs 2)

0.399

(0.55–2.92)

0.365

1.12

(0.14–8.85)

0.912

(b) Disease-specific survival

 Primary tumor site

   Trunk (vs Extremity)a

8.14

(1.10–60.06)

0.0397*

5.93

(0.76–46.21)

0.0894

 Surgical margin

      

   (R2, R1, R0)

2.70

(1.16–6.26)

0.0207*

2.23

(0.84–5.86)

0.106

 Genomic cluster

   Cluster 1 (vs 2)

2.86

(1.28–6.39)

0.0104*

3.18

(1.35–7.48)

8.07 × 10−3**

   Cluster 3 (vs 2)

1.38 × 10−8

(0–Inf)

0.999

1.55 × 10−7

(0–Inf)

0.998

  1. CI confidence interval, HR hazard ratio
  2. The results are presented for the univariate and multivariate Cox-regression analysis for progression-free and disease-specific survival, using clinical measures and genomic cluster. Kaplan–Meier survival curves according to the SCNA regions are shown in Fig. 3. *P < 0.05, **P < 0.01
  3. aTrunk includes abdomen, retroperitoneum, chest wall, and back, and extremity includes extremity, shoulder, and girdle
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