Fig. 2 | Nature Communications

Fig. 2

From: Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Fig. 2

MSN functionalization and characterisation. a Schematic showing the synthesis and surface modification of MSN with EGFR-targeting aptamers following carboxylation (negative charge; MSN-AP−) and amination (positive charge; MSN-AP). b–g TEM (b–d) and AFM (e–g) images of MSN, MSN-AP− and MSN-AP. h Size distribution. i PAGE electrophoresis showing 1, markers; 2, MSN; 3, free aptamer; 4, MSN mixed with AP; 5, MSN-AP-; 6, MSN-AP; 7, MSN-AP- after 8-h incubation in blood; 8, MSN-AP after 8-h incubation in blood. j Effects of MSN, MSN-AP− and MSN-AP on viability of endothelial cells (j) and human hepatocyte LO2 cells (k). n = 5 reduplications. Data presented as the mean ± s.e.m. Source data are provided as a Source Data file.

Back to article page