Table 1 Summary statistics of the Cox regression analysis and stepwise backward selection.

From: An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

 

TCGA

METABRIC

TAI

VDX

STK

UPP

MAINZ

STAM

UPSA

CAL

PNC

Immune clusters

           

 Cluster B vs Clusters A–C

0.38 (0.24–0.61)

0.72 (0.59–0.88)

0.63 (0.37–1.05)

0.47 (0.32–0.7)

0.47 (0.22–1)

0.51 (0.29–0.88)

0.34 (0.16–0.7)

0.65 (0.47–0.92)

0.57 (0.33–1.01)

0.22 (0.09–0.54)

0.55 (0.24–1.24)

 

<0.0001

0.001

0.078

<0.0001

0.049

0.02

0.004

0.014

0.053

0.001

0.151

ER status

           

 ER neg vs ER pos

0.54 (0.33–0.89)

       

2.37 (1.04–5.36)

  
 

0.015

       

0.039

  

PAM50

           

 Basal-like vs Her2

 

1.14 (0.86–1.5)

2.29 (1.02–5.1)

0.9 (0.49–1.65)

1.67 (0.6–4.67)

 

0.43 (0.14–1.35)

0.84 (0.46–1.53)

1.7 (0.72–4.03)

 

2 (0.66–6.07)

  

0.370

0.044

0.726

0.326

 

0.147

0.572

0.227

 

0.222

 Basal-like vs LumA

 

0.41 (0.31–0.54)

0.81 (0.34–1.93)

0.63 (0.37–1.08)

0.26 (0.09–0.78)

 

0.19 (0.07–0.5)

0.39 (0.25–0.61)

0.4 (0.16–1.04)

 

0.62 (0.14–2.68)

  

<0.0001

0.636

0.093

0.016

 

0.001

<0.0001

0.061

 

0.526

 Basal-like vs LumB

 

0.92 (0.72–1.19)

1.58 (0.71–3.53)

1.39 (0.85–2.26)

1.19 (0.53–2.68)

 

0.46 (0.19–1.1)

0.95 (0.64–1.41)

0.97 (0.38–2.5)

 

1.18 (0.42–3.33)

  

0.529

0.262

0.188

0.673

 

0.081

0.792

0.953

 

0.750

 Basal-like vs Normal

 

0.72 (0.5–1.04)

2.69 (1–7.22)

0.25 (0.06–1.06)

0.16 (0.02–1.28)

 

0.54 (0.18–1.63)

0.07 (0.01–0.48)

0.62 (0.2–1.89)

 

7.58 (0.86–66.95)

  

0.079

0.050

0.060

0.084

 

0.275

0.007

0.400

 

0.068

Lymph node status

           

 Node neg vs Node pos

 

2.15 (1.74–2.65)

   

2.59 (1.51–4.46)

 

1.64 (1.2–2.23)

  

1.35 (0.63–2.92)

  

<0.0001

   

<0.0001

 

0.002

  

0.443

Stage

           

 Stage 1 vs Stage 2

1.83 (0.91–3.69)

0.73 (0.58–0.92)

         
 

0.088

0.008

         

 Stage 1 vs Stage 3

2.2 (1.05–4.63)

1.38 (0.97–1.96)

         
 

0.037

0.073

         

 Stage 1 vs Stage 4

5.68 (2.18–14.82)

3.09 (1.43–6.68)

         
 

<0.0001

0.004

         

Age

           

 Continuous variable

1.03 (1.02–1.05

          
 

<0.0001

          

Tumor size

           

 Continuous variable

 

1.01 (1–1.01)

   

1.53 (1.24–1.89)

  

1.01 (1–1.02)

0.86 (0.68–1.09)

1.09 (0.89–1.33)

  

<0.0001

   

<0.0001

  

0.040

0.209

0.406

  1. Hazard ratio and 95% confidence interval are on the first row, p values from Cox proportional hazards model on the second row
  2. For each cohort, the best fitted model (variables independently explaining survival) are shown