Fig. 8
From: A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
CDK7 activates glucose transport in certain NSCLC. a Activated PIK3CA signals through PKCι to induce CDK7 phosphorylation. Phosphorylation of CDK7 activates it to phosphorylate RNA Polymerase II (RNA Pol II). This leads to transcription of GLUT1 mRNA, expression of the GLUT1 transporter, and transport of glucose across the cell membrane. b CDK7 inhibitor treatments block CDK7 activity, decreasing the phosphorylation of RNA Pol II. This leads to a decrease in GLUT1 mRNA and protein levels, and less glucose transport. Dotted lines are meant to represent the regulation of one protein by another but not necessarily a direct, linear interaction between the proteins.
