Fig. 2 | Nature Communications

Fig. 2

From: Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

Fig. 2

Mutation frequencies in iPSC clones base-edited by transient transfection. a Diagrammatic representation of experimental design for whole-genome sequencing analysis of iPSCs edited at the HEK3, RNF2 or EMX1 locus after transient transfection with either the plasmid or the RNA form of base editor. Clones transfected by a GFP-only plasmid vector were used as procedure controls for the analysis. b Mutation numbers in control iPSC clones and base-edited iPSC clones after plasmid or RNA transfection. c Fractions of mutations in control and base-edited iPSC clones. Source data for b and c are provided in the Source Data file.

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