Fig. 9
From: Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development
Summary cartoon depicting the dynamic expression pattern and function of Wnt-regulated Lgr5+ cells in the immature uterus. At P7, Lgr5+ cells are uniformly distributed throughout the endometrium and contribute to the development of both the LE and GE. After P14, Lgr5+ cells become restricted to the tips of developing glands and exclusively contribute to the development of GE. Wnt signaling is instrumental in regulating the activity of the Lgr5+ stem/progenitor cells at P14, likely mediated by interaction of Fzd10 with Wnt ligands supplied by both epithelial and stromal populations.
