Fig. 2: Inhibition of LRRK2 kinase activity increases GCase activity in DA neurons from PD patients. | Nature Communications

Fig. 2: Inhibition of LRRK2 kinase activity increases GCase activity in DA neurons from PD patients.

From: LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

Fig. 2

Examination of lysosomal GCase activity in LRRK2 G2019S DA neurons treated with the LRRK2 kinase inhibitor, MLi-2 (600 nM) a. Comparison of GCase activity in LRRK2 G2019S b and R1441C c DA neurons relative to isogenic controls and neurons treated with MLi-2 or a direct GCase modulating compound, 6166 (3 µM). GCase activity measured in DA neurons from two independent healthy controls treated with MLi-2 d. Comparison of GCase activity in GBA1 E326K e or N370S f DA neurons relative to isogenic controls and neurons treated with MLi-2 or 6166. The data are presented as the mean ± SEM, n = 3; *p < 0.05, **p < 0.01, ***p < 0.001 relative to untreated, one-way ANOVA followed by Tukey’s multiple comparison post hoc test. Source data are provided as a Source Data file.

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