Fig. 7: EP4 knockout in sensory nerve attenuates spinal pain behavior. | Nature Communications

Fig. 7: EP4 knockout in sensory nerve attenuates spinal pain behavior.

From: Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice

Fig. 7: EP4 knockout in sensory nerve attenuates spinal pain behavior.The alternative text for this image may have been generated using AI.

a–g Quantitative analysis of spinal pain-related behavior tests, including pressure hyperalgesia (a), spontaneous distance traveled (b), maximum speed (c), mean speed (d), active time (e) per 24 h, and hind paw withdrawal frequency responding to mechanical stimulation (0.7 mN; f and 3.9 mN; g) in EP4 −/− or EP4f/f mice overtime after LSI or sham surgery. *p < 0.05, **p < 0.01 compared with EP4f/f sham surgery mice, #p < 0.05, ##p < 0.01 compared with EP4f/f LSI surgery mice at the corresponding time points. n = 8 per group (a–g). Statistical significance was determined by multifactorial ANOVA, and all data are shown as means ± standard deviations. PWF paw withdraw frequency. Source data are provided as a Source Data file.

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