Fig. 3: Sex-specific genetic correlations across glycaemic traits and psychiatric traits.

Sex-specific genetic correlations of glycaemic traits (n = up to 140,583) with sex-combined psychiatric disorders (n = up to 77,096) and behavioural traits (n = up to 157,355). The autosomal genetic correlations were calculated by bivariate linkage disequilibrium score regression (LDSC). Coloured bars represent genetic correlations, error bars depict standard errors (s.e.) and asterisks indicate statistically significant genetic correlations with p values less than α = 0.0002. This threshold was calculated via the identification of the number of independent tests using matrix decomposition of the genetic correlation matrix and subsequent Bonferroni correction of α = 0.05 for 231 independent tests. ADHD = attention-deficit/hyperactivity disorder, Glu = fasting glucose, Ins = fasting insulin, IR = insulin resistance, adj = adjusted.