Table 1 Significant genetic correlations between psychiatric disorders, behavioural traits and body composition traits.

Psychiatric/behavioural trait	Body composition	r_g	s.e.	p
Group 1
Anorexia nervosa	Body fat %	−0.34	0.03	2.09 × 10⁻²⁷
Anorexia nervosa	Fat-free mass	−0.14	0.03	5.79 × 10⁻⁰⁶
Education years	Body fat %	−0.34	0.02	7.11 × 10⁻⁶⁰
Education years	Fat-free mass	−0.03	0.02	0.14 (n.s.)
OCD	Body fat %	−0.31	0.05	9.82 × 10⁻¹⁰
OCD	Fat-free mass	−0.12	0.04	0.01 (n.s.)
Schizophrenia	Body fat %	−0.09	0.02	7.30 × 10⁻⁰⁶
Schizophrenia	Fat-free mass	−0.08	0.02	2.00 × 10⁻⁰⁴
Group 2
ADHD	Body fat %	0.30	0.03	2.50 × 10⁻²¹
ADHD	Fat-free mass	0.17	0.03	3.84 × 10⁻¹¹
Smoking	Body fat %	0.29	0.03	3.59 × 10⁻²³
Smoking	Fat-free mass	0.15	0.03	9.94 × 10⁻⁰⁸
Alcohol dependence	Body fat %	0.23	0.06	2.00 × 10⁻⁰⁴
Alcohol dependence	Fat-free mass	0.04	0.05	0.45 (n.s.)
Insomnia	Body fat %	0.23	0.04	2.27 × 10⁻⁰⁸
Insomnia	Fat-free mass	0.06	0.03	0.11 (n.s.)

Note: The correlations were calculated using LDSC¹¹. The table presents the significant findings. The full results can be found in Supplementary Data 2. Bonferroni-corrected p value threshold: ɑ = 0.05/190 = 0.0002
LDSC linkage disequilibrium score regression, r_g genetic correlation, s.e. standard error, p p value, n.s. not significant after correction for multiple testing, ADHD attention-deficit/hyperactivity disorder, OCD obsessive compulsive disorder

Quick links

Search