Fig. 4
From: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
ASH2L interacts with the nucleosomal DNA through IDRs. a Structure prediction of ASH2LIDR. The structure of ASH2L IDR regions was not available and thus not assigned in the corresponding cryo-EM map (dashed circle). The structure prediction approach was employed to model ASH2L IDR regions as described in the STAR methods. Linker-IDR colored green and Loop-IDR colored blue in the ASH2LIDR model structure. b Stereo-view of the ASH2L-DPY30 model structure and its contacts with DNA. The structure of ASH2L is a composite from crystal structure of ASH2LSPRY (PDB ID: 5F6L)16 and the modeled ASH2LIDR. The schematics of ASH2L was shown at the bottom and key residues 202–207 in ASH2LIDR were highlighted in red.
