Fig. 6
From: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
The MLL1SET domain aligns at the nucleosome dyad. a MLL1SET (slate) and two copies of histone H3 (green) were highlighted against the faded MLL1RWSAD-NCP structure. The SAH molecule represented as a sphere and marked the catalytic active site of MLL1SET. b Schematic model of NCP recognition mediated by the MLL1 core complex. The I-loop of RbBP5 and the active site of MLL1SET were colored in blue and red, respectively.
