Fig. 7: Model of circadian regulation of memory retrieval.
From: Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
Both WT and dnBMAL1 mice show a time-of-day retrieval profile. However, dnBMAL1 mice show worse retrieval performance at any time compared to WT mice; dnBMAL1 mice show impairments in retrieval of weak and strong memories at ZT4 and ZT10, respectively, compared to WT mice. Phosphorylation of GluA1 at S845 is required for maintenance of retrieval performance.
