Fig. 5: Molecular level insights into the structure of aSyn fibrils amplified from patient brain extracts. | Nature Communications

Fig. 5: Molecular level insights into the structure of aSyn fibrils amplified from patient brain extracts.

From: Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

Fig. 5

a HD-exchange profiles of aSyn fibrils amplified from brain extracts of PD patients (left, green) and MSA patients (middle, purple). HD-exchange profiles of four de novo PMCA aSyn fibrils, which are not based on seeding/propagation, are shown in the right column (yellow to orange) together with the residue-specific average values for six de novo PMCA fibril samples. Error bars represent std. b PCA of protonation levels in aSyn fibrils (see text for further details). Independent repetition of HD exchange measurements for fibrils obtained from patient MSA5 are included (indicated by black arrows).

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