Table 1 Genetic characteristics of Pax5-het/Aid-het (1–5) and Pax5-het/Aid-KO (6–13) B-ALL.
From: Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID
Mouse number | Mouse age at disease (months) | Jak3 mutation in mouse* | JAK3 human homolog | Stat5b mutation in mouse* | Stat5b human homolog | Pax5 mutation in mouse* | Pax5 human homolog | Trp53 mutation in mouse* | Trp53 human homolog | Nras mutation in mouse* | Nras human homolog | Kras mutation in mouse* | Kras human homolog | Ptpn11 mutation in mouse* | Ptpn11 human homolog | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | L503 | 10 | R653H | R657Q | – | – | P80R | P80R | – | – | – | – | – | – | – | – |
2 | L519 | 15.4 | – | – | – | – | – | – | R169H | R175H | – | – | – | – | – | – |
3 | L517 | 17.4 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
4 | L499 | 17 | – | – | – | – | – | – | – | – | – | – | – | – | T472I | Not reported |
5 | L521 | 19.7 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
6 | I921 | 9.1 | – | – | – | – | G85A | G85R | – | – | – | – | – | – | – | – |
7 | I516 | 13.4 | – | – | – | – | – | – | – | – | – | – | – | – | S506L | S506L |
8 | V414 | 8 | – | – | – | – | – | – | R243Q | R249Q | – | – | – | – | E76K | E76K |
9 | V612 | 10.2 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
10 | V517 | 11.5 | – | – | – | – | – | – | – | – | Q61H | Q61K | – | – | – | – |
11 | V093 | 14.2 | – | – | A712E | V712E | c.213–2 A>T | c.213–1 G>T | – | – | – | – | G13R | G13R | – | – |
12 | V375 | 13.5 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
13 | I972 | 16.7 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
