Fig. 3: Physicochemical SERS fingerprints of molecular analytes using FASERS.
From: Surface enhanced Raman scattering artificial nose for high dimensionality fingerprinting
a Chemical structures of the four model analyte molecules. b–e Series of SERS spectra obtained from functionalized Au-nanopillars with various SAM-forming molecules: non-functionalized (bare), 1-propanethiol (3CH3), 3-mercapto-1-propanol (3OH), 3-mercaptopropionic acid (3COOH), 3-amino-1-propanethiol (3NH2), 1-undecanethiol (11CH3), 11-mercapto-1-undecanol (11OH), 11-mercaptoundecanoic acid (11COOH), 11-amino-1-undecanethiol (11NH2). b 500 µM p-phenylenediamine (p-PDA) in phosphate buffer (10 mM, pH 5.0), c 500 µM 4-aminophenylacetic acid (4-APA) in phosphate buffer (10 mM, pH 7.5), d 100 µM Rhodamine 6 g (R6G) in phosphate buffer (10 mM, pH 5.0), and e 500 µM folic acid (FA) in phosphate buffer (10 mM, pH 7.5). Solid lines and grey shaded areas represent mean and ± 1 s.d. of nine obtained spectra (N = 3, n = 3 spectra). f–i Peak analysis on the prominent peaks of the solutions; f p-PDA, g 4-APA, h R6G and i FA. Data represent the peak intensities determined from the nine spectra (N = 3, n = 3 spectra). ****p < 0.0001, ***p < 0.001, **p < 0.01 and *p < 0.05 based on one‐way ANOVA and Tukey’s honest significance test.
